![]() ![]() The two main types of ACS include unstable angina, in which myocardial cells are reversibly damaged, and acute myocardial infarction (AMI), when blood flow is completely blocked, resulting in myocardial cell death. ACS can be attributed to the rupture of unstable atherosclerotic plaques, which induces thrombus formation and leads to occlusion of a coronary artery. Acute coronary syndrome (ACS), a subcategory of CAD, occurs when blood flow to the heart is reduced, and myocardial cells are deprived of oxygen. A total of 48% of these deaths can be attributed to coronary artery disease (CAD). Program Director, Clinical Chemistry COMACC Fellowship at Hennepin County Medical Center, Department of Laboratory Medicine and Pathology.Ĭardiovascular disease (CVD) is the cause of more than 700,000 deaths in the USA each year. Research Director (PI) of ‘Cardiac Biomarkers Trials Laboratory’ of the Minneapolis Medical Research Foundation, 1982 to present (CLIA accredited lab). Medical Director, Richfield Clinic Laboratory of Hennepin County Medical Center, 2003 to present (COLA accredited lab). Forensic Toxicology Consultant, Hennepin County Medical Examiner’s Office, 1982 to present. Medical Director Point of Care Testing, Hennepin County Medical Center, 1995 to present (CAP accredited). Medical Director of Clinical Chemistry and Toxicology Laboratories, Hennepin County Medical Center, July 1982 to present. Professor, University of Minnesota School of Medicine, Department of Laboratory Medicine and Pathology, July 1995 to present. Medical Director of Clinical Laboratories, Hennepin County Medical Center, 1996 to present (accredited: CLIA, CAP, CAP POCT, CAP FUDT, ABFT, Joint Commission). Clinical Chemistry Postdoctoral Fellow, Washington University School of Medicine, Barnes Hospital, July 1980 to June 1982. Apple Education: 1975, BS, Rensselaer Polytechnic Institute, 1979, PhD, University of Minnesota, Chemistry, PhD Thesis: “Manipulation of the fatty acid composition of mammalian plasma membranes in culture”. She is a Research Assistant in the Cardiac Biomarker Trials Laboratory at Hennepin County Medical Center, Minneapolis, MN. Olaf College, Northfield, MN, and will be awarded a B.A. The i-STAT cTnI assay is a sensitive and precise monitor of cTnI, poised for point-of-care/near bedside clinical utilization for triage, diagnostics and risk management of acute coronary syndrome patients.Published by De Gruyter OctoCardiac troponin assays: a review of quantitative point-of-care devices and their efficacy in the diagnosis of myocardial infarctionīeret Amundson was educated at St. Regression analysis for the i-STAT cTnI between whole blood and plasma specimens and for whole blood between the i-STAT and Stratus CS cTnI assays demonstrated slopes of 1.06 and 0.89, respectively. An equimolar response within 5% was found for reduced and phosphorylated forms of TIC and IC complexes. The assay was not affected by common interferents. The 99th percentile reference limit was 0.08 microg/l. Total imprecision (CV) of 10% and 20% were seen at 0.09 and 0.07 microg/l, respectively. Factors studied included antibody specificity, detection limit, imprecision, linearity, assay specificity, sample type stability, interferences, reference limit determination and comparison vs. A total of 186 whole blood specimens (lithium heparin) were collected from patients presenting with symptoms suggestive of acute coronary syndromes (ACS) for correlation studies as well as from 162 healthy subjects for reference interval determination. Three different hospitals participated in a patient specimen and analytical validation study (n=186) for the i-STAT cTnI assay carried out in real time. This study determines the analytical characteristics of the i-STAT cardiac troponin I assay (cTnI i-STAT, Princeton, NJ), a 10-min POC assay, designed to be performed at the bedside. ![]()
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